SOLVO BIOTECHNOLOGY is the leading provider of transporter technology, assays and reagents.
The effect of drugs or other xenobiotics depend on their concentrations at the site(s) of action. The fate of administered compounds including drugs may largely depend on their interactions with transporter proteins. Transporters are present in all major pharmacologically relevant barriers in the intestine, liver, kidney, brain, placenta, and testis. They modulate the pharmacokinetic properties of endobiotics and xenobiotics, among others by limiting or enhancing oral absorption, influencing the distribution of compounds e.g. limiting drug entry into the brain, affecting metabolism through controlling cellular concentrations of the molecules, restricting or promoting excretion and toxicity of administered compounds. Similarly, drug-transporter interactions may modulate the bioavailability of other compounds, e.g. reduce their excretion rate, or when co-administered with an other drug may influence the efficacy of the drug(s). Thus, transporters may also be the site of drug-drug, drug-nutrient and drug-endobiotic interactions and therefore be responsible for many adverse drug reactions.
SOLVO BIOTECHNOLOGY provides "Turn-Key" comprehensive solution from various High Throughput in vitro to in vivo systems to guide drug discovery and development through the relevant transporter mediated Pharmacokinetic and drug-drug interactions (DDIs).
